Use Cases

Where teams start.
Where they go next.

Vivo delivers value across workflows, functions, and studies.

Use Case 01

Trial Oversight

Most study teams manage trial oversight the same way: collect updates from EDC, CTMS, CRO reports, vendor portals, and spreadsheets every week. Reconcile them manually. Build a status slide. Share it 3 days later. By then, something has changed.

Vivo replaces this cycle with a continuously updated operating picture.

Why current approaches fall short:

  • Data is current in individual systems but stale by the time it's assembled and shared
  • Risk detection relies on people noticing problems in exports, not the systems alerting them
  • Meeting preparation consumes hours that should be spent on execution
  • There is no consistent definition of "study status" across functions

How Vivo helps:

  • Trial Home shows what changed, what needs attention, and what actions are pending — continuously
  • Unified enrollment, site, vendor, protocol, safety, and data quality status in one view
  • Ask Vivo answers pre-meeting questions in seconds: "What changed since last week?"
  • Trial News summaries keep cross-functional teams aligned without manual reporting
  • Alerts, issue ownership, and follow-up tracked from one operating surface

Ask Vivo — Trial Oversight

What changed in trial status since the last study team meeting?
Are there any sites below 70% of enrollment plan right now?
Which vendors have outstanding deliverables this week?
What protocol deviations were logged in the past 30 days?

"We can now ask questions that used to take a week to answer — in seconds, with the source data attached."

→ Clinical Operations → Portfolio Leadership

Data Quality Workflow

1
Detect
Cross-system discrepancies, missingness, review-state gaps surfaced automatically
2
Triage
Prioritize by domain, subject, site, endpoint criticality, and milestone impact
3
Query / Resolve
Issue queries, assign ownership, track status, follow up across vendors and CROs
4
Re-review
Changed-since-review detection — see exactly what changed after prior sign-off
5
Prove Readiness
Lock-readiness evidence bundles with source records, provenance, and review history
Use Case 02

Data Quality & Readiness

Data quality issues often live between systems. EDC checks catch intra-system errors. But cross-system discrepancies — between labs and EDC, between safety database and EDC, between imaging and EDC — remain invisible until someone manually reconciles exports.

Vivo unifies data across sources and continuously monitors for patterns that matter: missing data, cross-system inconsistencies, records that changed after review, visit completeness gaps, and lock-readiness blockers.

How Vivo helps:

  • Cross-system discrepancy detection — EDC vs. labs, safety, imaging, eCOA, IRT, vendor files
  • Completeness, missingness, and visit adherence monitoring by domain and subject
  • Changed-since-review detection — catch what moved after a prior review cycle closed
  • Source provenance, mapping history, and transformation transparency visible in product
Use Case 03

Enrollment & Retention

Enrollment delays are the most common source of trial timeline risk — and the most preventable. Screen failure rates, site activation lag, protocol criterion barriers, retention dropout patterns, and site-level underperformance are often visible in the data weeks before they surface in a status report.

Vivo connects enrollment, screening, randomization, visit adherence, dropout, IRT, CTMS, and site data into an early-warning picture — surfaced through Ask Vivo questions, alerts, and continuous monitoring.

Vivo helps teams understand:

  • Which sites are below enrollment plan — and by how much, and for how long
  • Which inclusion/exclusion criteria are driving the most screen failures
  • Whether retention dropout is isolated to specific sites, cohorts, or visits
  • Which site activations are lagging and creating pipeline risk
  • Enrollment trajectory vs. plan across countries, regions, and time

Enrollment Intelligence — Ask Vivo

Enrollment & Screen Failures
Question
Which IE criteria are driving the most screen failures across all sites?
Answer
IE-03 (prior CNS medication exclusion) accounts for 38% of all screen failures. IE-07 (MMSE threshold) accounts for 22%. Both are site 104 and site 211 patterns. Site 104 has not adjusted its pre-screening approach since activation.
↗ Source: EDC screening log · Protocol v3.2 IE criteria · Site activation records

Safety Context — Subject Level

AE Cluster Signal
Injection-site reactions 3.2× higher at Site 104 vs. study mean. All 7 cases in Cohort B (high dose). No clustering in Cohorts A or C.
Lab Context
3 of 7 subjects show elevated CRP and ESR. No dose holds or protocol deviations recorded at Site 104 for these subjects.
Evidence Package Ready
Source records, protocol context, MedDRA coding, reviewer comments assembled for medical monitor review.
Blinding-aware · Role-restricted · Audit-ready
Use Case 04

Safety Review

Safety signals need clinical context to be actionable. An AE is more meaningful when you can immediately see the subject's dose history, concomitant medications, labs, prior AEs, and protocol context — not just the event record in isolation.

Vivo gives safety and medical monitoring teams subject-level context for signals, site- and cohort-level aggregation to detect patterns, and source-backed evidence packages for review meetings, DSMB preparation, and safety reporting.

Key capabilities:

  • Subject-level safety context: AEs, labs, conmeds, dose, MedHx, visit adherence
  • Site, cohort, and dose-level signal aggregation and comparison
  • Special interest event monitoring with protocol-defined thresholds
  • Blinding-aware access controls for active trial environments
  • Evidence packages for review meetings, DSMBs, and safety reports

"Vivo is our new best friend."

Medical Monitor · Phase 2 Rare Disease Trial
Use Case 05

Portfolio Intelligence

Clinical development leaders rarely lack information. They lack the right information, organized for the right decision, at the right time. Vivo gives portfolio and development leadership a shared operating picture across studies that is continuously updated, drill-able, and source-backed.

Rather than waiting for each study team to assemble and share a periodic update, leaders can see portfolio risk, performance, and change in near real-time — and ask questions across studies.

Portfolio Ask Vivo examples:

Which studies have the highest execution risk this month?
Which sites have reported the most protocol deviations across phases for an asset?
What changed across the portfolio since last week's review?
Which milestones are under pressure in Q3?

Portfolio Visibility

Study OS-204 · OncologyHigh Risk
Enrollment −18% · 2 site activations overdue · Vendor data lag
Study CNS-107 · Alzheimer'sWatch
Protocol deviation rate +22% over 4 weeks · Site 211 flagged
Study IMM-033 · I&I Phase 3On Track
Enrollment on plan · Data quality clean · No open alerts
Study RD-019 · Rare DiseaseOn Track
Lock readiness progressing · 2 open DM queries
4 active studies · Updated 2h ago
Use Case 06

Real-Time Trial Readiness

The FDA's new operating models and evolving inspection expectations call for evidence-backed documentation of what happened, when it happened, who acted, and what changed. Vivo is designed for this operating model from the ground up.

Continuous Oversight

AI-RBQM monitors for risk continuously — not at periodic review cycles. Signals, alerts, issues, and evidence packages are preserved as they happen.

Source-Backed Evidence

Every answer, alert, and issue links back to the underlying source records with provenance and transformation history — inspection-ready evidence on demand.

Human Review & Audit Trails

All workflows include reviewer comments, decision records, timestamps, and attribution. AI assists — humans decide and sign.

FDA CSA & Decentralized Trial Ready

Purpose-built for FDA Computer System Assurance guidance. Supports decentralized, hybrid, and traditional trial designs.

"Clinical AI should accelerate insight without weakening scientific discipline."

Explore Trust & Compliance →

Learn how Vivo can augment your team.